The 3 deadliest drugs in America are all totally legal
When it comes to deadliness, no single substance comes close to tobacco. To put its risk in perspective, fewer Americans die from reported drug overdoses, traffic accidents and homicides combined than tobacco-caused health problems like lung cancer and heart disease.
Cigarette smoking is linked to one in five deaths in the US each year, according to the CDC. Nearly 42,000 of the 480,000 deaths are caused by secondhand smoke.